The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly important
M. CHIARUCCI, R. MOCCI, L.-D. SYNTRIVANIS, G. CERA, A. MAZZANTI, M. BANDINI (2014). Merging Synthesis and Enantioselectiv e Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction. SYNFACTS, 10(1), 68-68 [10.1055/s-0033-1340458].
Merging Synthesis and Enantioselectiv e Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction
CHIARUCCI, MICHEL;CERA, GIANPIERO;MAZZANTI, ANDREA;BANDINI, MARCO
2014
Abstract
The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly importantFile in questo prodotto:
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