The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly important
Merging Synthesis and Enantioselectiv e Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction
CHIARUCCI, MICHEL;CERA, GIANPIERO;MAZZANTI, ANDREA;BANDINI, MARCO
2014
Abstract
The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly importantFile in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
