Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.
A. Palladini, A. Astolfi, S. Croci, C. De Giovanni, G. Nicoletti, A. Rosolen, et al. (2006). Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role. EUROPEAN JOURNAL OF CANCER, 42, 680-687 [10.1016/j.ejca.2005.11.024].
Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role.
PALLADINI, ARIANNA;ASTOLFI, ANNALISA;CROCI, STEFANIA;DE GIOVANNI, CARLA;NICOLETTI, GIORDANO;LOLLINI, PIER LUIGI;LANDUZZI, LORENA;NANNI, PATRIZIA
2006
Abstract
Several autocrine and paracrine growth factor circuits have been found in human rhabdomyosarcoma cells. In this study we show that endothelin-3 (ET-3), a vasoactive peptide, is produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. We did not find evidence of a significant autocrine loop; nevertheless ET-3 produced by rhabdomyosarcoma cells can act as a paracrine factor, since it promotes migration of endothelial cells. Moreover ET-3 is present in plasma of mice bearing xenografts of human rhabdomyosarcoma cells, and may be potential new marker of the human rhabdomyosarcoma to be studied further.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
