PURPOSE: The aim of the present study was to assess serum lipid levels before and after treatment with oxcarbazepine in children with epilepsy. METHODS: We measured total cholesterol (TC), triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) in 28 patients whereas only TC levels in 11 patients, during baseline period and at 3 months after the beginning of therapy with oxcarbazepine. RESULTS: During baseline period, median values were: 4.38 (IQR=4.12-5.03) mmol/L for TC levels, 1.72(IQR=1.42-2.01) mmol/L for HDL-C levels and 1.54 (IQR=1.29-1.96) mmol/L for TGs levels. At three months, median values were: 4.38 (4.10-4.95) mmol/L for TC levels (p<0.05), 1.57(1.34-1.93) mmol/L for HDL-C levels (p<0.005) and 1.8(1.23-2.34) mmol/L for TGs levels (p<0.05). CONCLUSIONS: Median serum lipid levels remained in the normal range, despite an increasing-trend at three months of treatment with oxcarbazepine. Further studies are necessary to confirm these results.
Franzoni E., Marchiani V., Cecconi I., Moscano F.C., Gualandi S., Garone C., et al. (2006). Preliminary report on effects of oxcarbazepine-treatment on serum lipid levels in children. EUROPEAN JOURNAL OF NEUROLOGY, 13(12), 1389-1391 [10.1111/j.1468-1331.2006.01535.x].
Preliminary report on effects of oxcarbazepine-treatment on serum lipid levels in children.
FRANZONI, EMILIO;GUALANDI, STEFANO;GARONE, CATERINA;
2006
Abstract
PURPOSE: The aim of the present study was to assess serum lipid levels before and after treatment with oxcarbazepine in children with epilepsy. METHODS: We measured total cholesterol (TC), triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) in 28 patients whereas only TC levels in 11 patients, during baseline period and at 3 months after the beginning of therapy with oxcarbazepine. RESULTS: During baseline period, median values were: 4.38 (IQR=4.12-5.03) mmol/L for TC levels, 1.72(IQR=1.42-2.01) mmol/L for HDL-C levels and 1.54 (IQR=1.29-1.96) mmol/L for TGs levels. At three months, median values were: 4.38 (4.10-4.95) mmol/L for TC levels (p<0.05), 1.57(1.34-1.93) mmol/L for HDL-C levels (p<0.005) and 1.8(1.23-2.34) mmol/L for TGs levels (p<0.05). CONCLUSIONS: Median serum lipid levels remained in the normal range, despite an increasing-trend at three months of treatment with oxcarbazepine. Further studies are necessary to confirm these results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
