PURPOSE: The aim of the present study was to assess serum lipid levels before and after treatment with oxcarbazepine in children with epilepsy. METHODS: We measured total cholesterol (TC), triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) in 28 patients whereas only TC levels in 11 patients, during baseline period and at 3 months after the beginning of therapy with oxcarbazepine. RESULTS: During baseline period, median values were: 4.38 (IQR=4.12-5.03) mmol/L for TC levels, 1.72(IQR=1.42-2.01) mmol/L for HDL-C levels and 1.54 (IQR=1.29-1.96) mmol/L for TGs levels. At three months, median values were: 4.38 (4.10-4.95) mmol/L for TC levels (p<0.05), 1.57(1.34-1.93) mmol/L for HDL-C levels (p<0.005) and 1.8(1.23-2.34) mmol/L for TGs levels (p<0.05). CONCLUSIONS: Median serum lipid levels remained in the normal range, despite an increasing-trend at three months of treatment with oxcarbazepine. Further studies are necessary to confirm these results.
Preliminary report on effects of oxcarbazepine-treatment on serum lipid levels in children.
FRANZONI, EMILIO;GUALANDI, STEFANO;GARONE, CATERINA;
2006
Abstract
PURPOSE: The aim of the present study was to assess serum lipid levels before and after treatment with oxcarbazepine in children with epilepsy. METHODS: We measured total cholesterol (TC), triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) in 28 patients whereas only TC levels in 11 patients, during baseline period and at 3 months after the beginning of therapy with oxcarbazepine. RESULTS: During baseline period, median values were: 4.38 (IQR=4.12-5.03) mmol/L for TC levels, 1.72(IQR=1.42-2.01) mmol/L for HDL-C levels and 1.54 (IQR=1.29-1.96) mmol/L for TGs levels. At three months, median values were: 4.38 (4.10-4.95) mmol/L for TC levels (p<0.05), 1.57(1.34-1.93) mmol/L for HDL-C levels (p<0.005) and 1.8(1.23-2.34) mmol/L for TGs levels (p<0.05). CONCLUSIONS: Median serum lipid levels remained in the normal range, despite an increasing-trend at three months of treatment with oxcarbazepine. Further studies are necessary to confirm these results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
