Herein we describe the case of a patient with primary diffuse leptomeningeal gliomatosis (PDLG). After surgery and ventriculoperitoneal shunt placement, due to poor general conditions, the patient was not eligible for radiotherapy. For this reason we decided to start a systemic chemotherapy treatment with Temozolomide (150 mg/m2 per day for 5 days every 4 weeks). After three cycles a partial response was achieved with a clear improvement of general conditions. In our knowledge, this is the first time that PDLG treatment with Temozolomide has been described.
Case report: temozolomide induced partial response in a primary diffuse leptomeningeal gliomatosis patient / G. Cavallo; E. Franceschi; L. Scopece; R. Degli Esposti; R. Conforti ; E. Palmerini; M.P. Foschini; A.F. Marliani; L. Crinò.. - In: JOURNAL OF NEURO-ONCOLOGY. - ISSN 0167-594X. - STAMPA. - 73:(2005), pp. 261-264. [10.1007/s11060-004-5672-5]
Case report: temozolomide induced partial response in a primary diffuse leptomeningeal gliomatosis patient.
PALMERINI, EMANUELA;FOSCHINI, MARIA PIA;
2005
Abstract
Herein we describe the case of a patient with primary diffuse leptomeningeal gliomatosis (PDLG). After surgery and ventriculoperitoneal shunt placement, due to poor general conditions, the patient was not eligible for radiotherapy. For this reason we decided to start a systemic chemotherapy treatment with Temozolomide (150 mg/m2 per day for 5 days every 4 weeks). After three cycles a partial response was achieved with a clear improvement of general conditions. In our knowledge, this is the first time that PDLG treatment with Temozolomide has been described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.