We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P < 0.01) in blood pressure, heart rate, endothelin-1 and catecholamine levels, whereas it did not change the low basal levels of nitric oxide. In healthy subjects (n = 20) the test significantly (P < 0.01) decreased endothelin-1 without affecting nitric oxide. The low basal levels of nitric oxide and the high plasma concentration of endothelin-1 after psychological stress cannot be explained by an impaired release from the limited ischemic lesions alone. This suggests a diffuse microvascular derangement that aggravates the course of peripheral microvascular ischemic lesions.
Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis / Fontana F;Bernardi P;Lanfranchi G;Conti E;Spampinato S;Di Toro R;Bonafè F;Coccheri S. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 26:(2005), pp. 2487-2490. [10.1016/j.peptides.2005.06.001]
Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis.
FONTANA, FIORELLA;BERNARDI, PASQUALE;SPAMPINATO, SANTI MARIO;DI TORO, ROSANNA;BONAFÈ, FRANCESCA;COCCHERI, SERGIO
2005
Abstract
We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P < 0.01) in blood pressure, heart rate, endothelin-1 and catecholamine levels, whereas it did not change the low basal levels of nitric oxide. In healthy subjects (n = 20) the test significantly (P < 0.01) decreased endothelin-1 without affecting nitric oxide. The low basal levels of nitric oxide and the high plasma concentration of endothelin-1 after psychological stress cannot be explained by an impaired release from the limited ischemic lesions alone. This suggests a diffuse microvascular derangement that aggravates the course of peripheral microvascular ischemic lesions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.