We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P < 0.01) in blood pressure, heart rate, endothelin-1 and catecholamine levels, whereas it did not change the low basal levels of nitric oxide. In healthy subjects (n = 20) the test significantly (P < 0.01) decreased endothelin-1 without affecting nitric oxide. The low basal levels of nitric oxide and the high plasma concentration of endothelin-1 after psychological stress cannot be explained by an impaired release from the limited ischemic lesions alone. This suggests a diffuse microvascular derangement that aggravates the course of peripheral microvascular ischemic lesions.

Fontana F, Bernardi P, Lanfranchi G, Conti E, Spampinato S, Di Toro R, et al. (2005). Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis. PEPTIDES, 26, 2487-2490 [10.1016/j.peptides.2005.06.001].

Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis.

FONTANA, FIORELLA;BERNARDI, PASQUALE;SPAMPINATO, SANTI MARIO;DI TORO, ROSANNA;BONAFÈ, FRANCESCA;COCCHERI, SERGIO
2005

Abstract

We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P < 0.01) in blood pressure, heart rate, endothelin-1 and catecholamine levels, whereas it did not change the low basal levels of nitric oxide. In healthy subjects (n = 20) the test significantly (P < 0.01) decreased endothelin-1 without affecting nitric oxide. The low basal levels of nitric oxide and the high plasma concentration of endothelin-1 after psychological stress cannot be explained by an impaired release from the limited ischemic lesions alone. This suggests a diffuse microvascular derangement that aggravates the course of peripheral microvascular ischemic lesions.
2005
Fontana F, Bernardi P, Lanfranchi G, Conti E, Spampinato S, Di Toro R, et al. (2005). Endothelin-1 response to mental stress in early ischemic lesions of the extremities due to systemic sclerosis. PEPTIDES, 26, 2487-2490 [10.1016/j.peptides.2005.06.001].
Fontana F;Bernardi P;Lanfranchi G;Conti E;Spampinato S;Di Toro R;Bonafè F;Coccheri S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/22748
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