Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.

Stromberg F, Hansson AC, Rimondini R, Sommer W (2004). c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat. BRAIN RESEARCH, 1000(1-2), 192-194 [10.1016/j.brainres.2003.10.061].

c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat

Rimondini R;
2004

Abstract

Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
2004
Stromberg F, Hansson AC, Rimondini R, Sommer W (2004). c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat. BRAIN RESEARCH, 1000(1-2), 192-194 [10.1016/j.brainres.2003.10.061].
Stromberg F; Hansson AC; Rimondini R; Sommer W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/22278
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