Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat / Stromberg F; Hansson AC; Rimondini R; Sommer W. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 1000:1-2(2004), pp. 192-194. [10.1016/j.brainres.2003.10.061]
c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat
Rimondini R;
2004
Abstract
Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
