The aim of this research was to study the release performance of solid lipid microparticles (SLMs) in various biorelevant dissolution media simulating the conditions of the gastric tract and the proximal human intestine. SLMs with different lipid composition and dimensions were prepared by spray congealing technology and characterized. The results indicate that SLMs release behavior is not affected by the media composition in the gastric tract. The fed state only influenced the release behavior of small size particles constituted by the triglyceride. On the contrary, the fluid simulating the fasted state in the small intestine is a discriminating medium for SLMs with respect to compendial medium, especially for small size fractions. Thus the dissolution behavior of SMLs in biorelevant media seems particularly affected by their lipid composition and their particle size rather than the media composition.

A Comprehensive Study of Solid Lipid Microparticles (SLMs) Behavior in Biorelevant Dissolution Media

ALBERTINI, BEATRICE;DI SABATINO, MARCELLO;PASSERINI, NADIA
2013

Abstract

The aim of this research was to study the release performance of solid lipid microparticles (SLMs) in various biorelevant dissolution media simulating the conditions of the gastric tract and the proximal human intestine. SLMs with different lipid composition and dimensions were prepared by spray congealing technology and characterized. The results indicate that SLMs release behavior is not affected by the media composition in the gastric tract. The fed state only influenced the release behavior of small size particles constituted by the triglyceride. On the contrary, the fluid simulating the fasted state in the small intestine is a discriminating medium for SLMs with respect to compendial medium, especially for small size fractions. Thus the dissolution behavior of SMLs in biorelevant media seems particularly affected by their lipid composition and their particle size rather than the media composition.
2013
Emerging challenges for global delivery
1
2
Beatrice Albertini; Marcello Di Sabatino; and Nadia Passerini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/220283
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