Enantioselective gold(I) catalysis is receiving a growing level of credit in the field of asymmetric synthesis. After a pioneering work in the mid-1980s the area remained almost silent for several years, until densely substituted diphosphine chiral ligands were disclosed as competent chiral units for gold-catalyzed stereoselective manipulation of unactivated unsaturated hydrocarbons. The chemistry of alkynes, allenes and most recently also alkenes received significant benefits from the latter developments. More recently, ad hoc designed chiral monodentate ligands have risen to prominence in producing robust, highly tunable (electronic and steric) and efficient chiral cationic mononuclear gold species for asymmetric transformations. In this scenario, electron-deficient phosphorus-based (i.e., phosphoramidites, phosphites) but also axially chiral electron-rich carbene ligands deserve particular mention and the corresponding applications will be summarized herein.

Gianpiero Cera, Marco Bandini (2013). Enantioselective Gold(I) Catalysis with Chiral Monodentate Ligands. ISRAEL JOURNAL OF CHEMISTRY, 53, 848-855 [10.1002/ijch.201300029].

Enantioselective Gold(I) Catalysis with Chiral Monodentate Ligands

CERA, GIANPIERO;BANDINI, MARCO
2013

Abstract

Enantioselective gold(I) catalysis is receiving a growing level of credit in the field of asymmetric synthesis. After a pioneering work in the mid-1980s the area remained almost silent for several years, until densely substituted diphosphine chiral ligands were disclosed as competent chiral units for gold-catalyzed stereoselective manipulation of unactivated unsaturated hydrocarbons. The chemistry of alkynes, allenes and most recently also alkenes received significant benefits from the latter developments. More recently, ad hoc designed chiral monodentate ligands have risen to prominence in producing robust, highly tunable (electronic and steric) and efficient chiral cationic mononuclear gold species for asymmetric transformations. In this scenario, electron-deficient phosphorus-based (i.e., phosphoramidites, phosphites) but also axially chiral electron-rich carbene ligands deserve particular mention and the corresponding applications will be summarized herein.
2013
Gianpiero Cera, Marco Bandini (2013). Enantioselective Gold(I) Catalysis with Chiral Monodentate Ligands. ISRAEL JOURNAL OF CHEMISTRY, 53, 848-855 [10.1002/ijch.201300029].
Gianpiero Cera; Marco Bandini
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/219865
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 62
  • ???jsp.display-item.citation.isi??? 61
social impact