The Povarov reaction provides a straightforward and modular entry to 1,2,3,4-tetrahydroquinolines (THQs). Despite its importance, it was only very recently that several highly efficient catalytic asymmetric protocols for this reaction have been developed,as summarized in this review which falls on the 50th anniversary of Povarov’s pioneering disclosure. Furthermore, this review collects and critically discusses the interrupted versions of the reaction,often featuring intriguing and still unclear mechanicistic pathways.
Catalytic Asymmetric Aza-Diels–Alder Reactions: The Povarov Cycloaddition Reaction / Mariafrancesca Fochi; Lorenzo Caruana; Luca Bernardi. - In: SYNTHESIS. - ISSN 0039-7881. - STAMPA. - 46:2(2014), pp. 135-157. [10.1055/s-0033-1338581]
Catalytic Asymmetric Aza-Diels–Alder Reactions: The Povarov Cycloaddition Reaction
FOCHI, MARIAFRANCESCA;CARUANA, LORENZO;BERNARDI, LUCA
2014
Abstract
The Povarov reaction provides a straightforward and modular entry to 1,2,3,4-tetrahydroquinolines (THQs). Despite its importance, it was only very recently that several highly efficient catalytic asymmetric protocols for this reaction have been developed,as summarized in this review which falls on the 50th anniversary of Povarov’s pioneering disclosure. Furthermore, this review collects and critically discusses the interrupted versions of the reaction,often featuring intriguing and still unclear mechanicistic pathways.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
