Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.
Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach / Lorenzo Caruana;Mariafrancesca Fochi;Mauro Comes Franchini;Silvia Ranieri;Andrea Mazzanti;Luca Bernardi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 50:(2014), pp. 445-447. [10.1039/c3cc47841f]
Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach
CARUANA, LORENZO;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;RANIERI, SILVIA;MAZZANTI, ANDREA;BERNARDI, LUCA
2014
Abstract
Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
