Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.
Lorenzo Caruana, Mariafrancesca Fochi, Mauro Comes Franchini, Silvia Ranieri, Andrea Mazzanti, Luca Bernardi (2014). Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach. CHEMICAL COMMUNICATIONS, 50, 445-447 [10.1039/c3cc47841f].
Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach
CARUANA, LORENZO;FOCHI, MARIAFRANCESCA;COMES FRANCHINI, MAURO;RANIERI, SILVIA;MAZZANTI, ANDREA;BERNARDI, LUCA
2014
Abstract
Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities and as single diastereoisomers.File in questo prodotto:
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