Chronic Eosinophilic Leukemia (CEL) is a chronic myeloproliferative disorder characterized by a persistent hypereosinophilia eventually associated with organ dysfunction. Recently, a fusion gene, FIP1-like 1 (FIP1L1)-PDGFR-alpha, has been found to be involved in some patients with CEL responsive to imatinib. We report a case of FIP1L1-PDGFR-alpha positive CEL, with soft tissue and skeletal involvement, where a complete molecular and imaging response to imatinib was documented
Soft tissue and skeletal involvement in FIP1L1-PDGFR-A positive chronic eosinophilic leukemia: imatinib mesylate may induce complete molecular and imaging remission
MALAGOLA, MICHELE;MARTINELLI, GIOVANNI;RONDONI, MICHELA;OTTAVIANI E;PICCALUGA, PIER PAOLO;RICCI, PAOLO;BACCARANI, MICHELE
2004
Abstract
Chronic Eosinophilic Leukemia (CEL) is a chronic myeloproliferative disorder characterized by a persistent hypereosinophilia eventually associated with organ dysfunction. Recently, a fusion gene, FIP1-like 1 (FIP1L1)-PDGFR-alpha, has been found to be involved in some patients with CEL responsive to imatinib. We report a case of FIP1L1-PDGFR-alpha positive CEL, with soft tissue and skeletal involvement, where a complete molecular and imaging response to imatinib was documentedFile in questo prodotto:
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