Chronic Eosinophilic Leukemia (CEL) is a chronic myeloproliferative disorder characterized by a persistent hypereosinophilia eventually associated with organ dysfunction. Recently, a fusion gene, FIP1-like 1 (FIP1L1)-PDGFR-alpha, has been found to be involved in some patients with CEL responsive to imatinib. We report a case of FIP1L1-PDGFR-alpha positive CEL, with soft tissue and skeletal involvement, where a complete molecular and imaging response to imatinib was documented
MALAGOLA M, MARTINELLI G., RONDONI M, OTTAVIANI E, PICCALUGA PP, RICCI P, et al. (2004). Soft tissue and skeletal involvement in FIP1L1-PDGFR-A positive chronic eosinophilic leukemia: imatinib mesylate may induce complete molecular and imaging remission. HAEMATOLOGICA, 89(8), 85-86.
Soft tissue and skeletal involvement in FIP1L1-PDGFR-A positive chronic eosinophilic leukemia: imatinib mesylate may induce complete molecular and imaging remission
MALAGOLA, MICHELE;MARTINELLI, GIOVANNI;RONDONI, MICHELA;OTTAVIANI E;PICCALUGA, PIER PAOLO;RICCI, PAOLO;BACCARANI, MICHELE
2004
Abstract
Chronic Eosinophilic Leukemia (CEL) is a chronic myeloproliferative disorder characterized by a persistent hypereosinophilia eventually associated with organ dysfunction. Recently, a fusion gene, FIP1-like 1 (FIP1L1)-PDGFR-alpha, has been found to be involved in some patients with CEL responsive to imatinib. We report a case of FIP1L1-PDGFR-alpha positive CEL, with soft tissue and skeletal involvement, where a complete molecular and imaging response to imatinib was documented| File | Dimensione | Formato | |
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