The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.
Dario Braga, Lucia Maini, Fabrizia Grepioni (2013). Mechanochemical preparation of co-crystals. CHEMICAL SOCIETY REVIEWS, 42, 7638-7648 [10.1039/c3cs60014a].
Mechanochemical preparation of co-crystals
BRAGA, DARIO;MAINI, LUCIA;GREPIONI, FABRIZIA
2013
Abstract
The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
