The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.
Mechanochemical preparation of co-crystals / Dario Braga;Lucia Maini;Fabrizia Grepioni. - In: CHEMICAL SOCIETY REVIEWS. - ISSN 0306-0012. - STAMPA. - 42:(2013), pp. 7638-7648. [10.1039/c3cs60014a]
Mechanochemical preparation of co-crystals
BRAGA, DARIO;MAINI, LUCIA;GREPIONI, FABRIZIA
2013
Abstract
The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in "old" solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
