Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
Novel pharmaceutical compositions through co-crystallization of racetams and Li+ salts / Johan Wouters;Fabrizia Grepioni;Dario Braga;Rafal M. Kaminski;Sandrine Rome;Luc Aerts;Luc Quéré. - In: CRYSTENGCOMM. - ISSN 1466-8033. - ELETTRONICO. - 15:(2013), pp. 8898-8902. [10.1039/c3ce41539b]
Novel pharmaceutical compositions through co-crystallization of racetams and Li+ salts
GREPIONI, FABRIZIA;BRAGA, DARIO;
2013
Abstract
Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
