Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.
Johan Wouters, Fabrizia Grepioni, Dario Braga, Rafal M. Kaminski, Sandrine Rome, Luc Aerts, et al. (2013). Novel pharmaceutical compositions through co-crystallization of racetams and Li+ salts. CRYSTENGCOMM, 15, 8898-8902 [10.1039/c3ce41539b].
Novel pharmaceutical compositions through co-crystallization of racetams and Li+ salts
GREPIONI, FABRIZIA;BRAGA, DARIO;
2013
Abstract
Grinding of solid brivaracetam (BRV) and seletracetam (SEL) with inorganic lithium salts yields original ionic co-crystals (ICCs) characterized by markedly different thermal properties with respect to pure racetams; solid products have been characterized by single crystal crystallography. It is suggested that co-crystallizing lithium with some racetams could lead to a pharmacologically relevant synergetic association and to development of an original drug substance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
