A 55-year-old Caucasian man who had received a second kidney graft in July 1993, was switched from cyclosporine to tacrolimus in June 2000 due to deterioration of renal function. Thereafter, he began to complain of muscle cramps in both quadriceps with an increased CPK and EMG findings of polyneuropathy. A muscle biopsy demonstrated acute myositis. Prednisone was administered with amelioration of the patient's symptoms, but with persistently increased CPK and myoglobin levels. In February 2001, mycophenolate mofetil was introduced and tacrolimus tapered to 3 mg daily to seek a toxic role of this immunosuppressant, since there was no other cause of myositis. A sudden decrease in CPK was observed, but the complete normalization took place only after its withdrawal in September 2002. This case represents a tacrolimus-associated myositis.

Orlandi V, Campieri C, Mosconi G, D'Arcangelo GL, Feliciangeli G, Scolari MP, et al. (2004). Tacrolimus-associated myositis: a case report in a renal transplant patient. TRANSPLANTATION PROCEEDINGS, 36(3), 708-710 [10.1016/j.transproceed.2004.03.018].

Tacrolimus-associated myositis: a case report in a renal transplant patient.

ORLANDI, VALENTINA;CAMPIERI, CLAUDIO;MOSCONI, GIOVANNI;LIVIANO D'ARCANGELO, GIOVANNI;FELICIANGELI, GIORGIO;SCOLARI, MARIA;STEFONI, SERGIO
2004

Abstract

A 55-year-old Caucasian man who had received a second kidney graft in July 1993, was switched from cyclosporine to tacrolimus in June 2000 due to deterioration of renal function. Thereafter, he began to complain of muscle cramps in both quadriceps with an increased CPK and EMG findings of polyneuropathy. A muscle biopsy demonstrated acute myositis. Prednisone was administered with amelioration of the patient's symptoms, but with persistently increased CPK and myoglobin levels. In February 2001, mycophenolate mofetil was introduced and tacrolimus tapered to 3 mg daily to seek a toxic role of this immunosuppressant, since there was no other cause of myositis. A sudden decrease in CPK was observed, but the complete normalization took place only after its withdrawal in September 2002. This case represents a tacrolimus-associated myositis.
2004
Orlandi V, Campieri C, Mosconi G, D'Arcangelo GL, Feliciangeli G, Scolari MP, et al. (2004). Tacrolimus-associated myositis: a case report in a renal transplant patient. TRANSPLANTATION PROCEEDINGS, 36(3), 708-710 [10.1016/j.transproceed.2004.03.018].
Orlandi V; Campieri C; Mosconi G; D'Arcangelo GL; Feliciangeli G; Scolari MP; Stefoni S.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/19162
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 12
social impact