The iron complex [Fp][OTf] {Fp(+) = [Fe(CO)(2)(Cp)](+), OTf- = SO3CF3-} is an efficient catalyst for the direct substitution of the OH group in ferrocenylmethanol [Fc-CH2OH] by thiols, aromatic amines, diphenylphosphane, and carbon nucleophiles (furan, pyrrole, and indole). This approach offers a convenient route to ferrocenes containing side chains with different functional groups. The advantages of the method are associated with the use of a catalyst based on iron, which is a nontoxic and readily available transition metal, and in the direct OH substitution, which produces water as the only byproduct.
Rita Mazzoni, Mauro Salmi, Stefano Zacchini, Valerio Zanotti (2013). Iron-Catalyzed Ferrocenylmethanol OH Substitution by S, N, P, and C Nucleophiles. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2013, 3710-3718 [10.1002/ejic.201300239].
Iron-Catalyzed Ferrocenylmethanol OH Substitution by S, N, P, and C Nucleophiles
MAZZONI, RITA;ZACCHINI, STEFANO;ZANOTTI, VALERIO
2013
Abstract
The iron complex [Fp][OTf] {Fp(+) = [Fe(CO)(2)(Cp)](+), OTf- = SO3CF3-} is an efficient catalyst for the direct substitution of the OH group in ferrocenylmethanol [Fc-CH2OH] by thiols, aromatic amines, diphenylphosphane, and carbon nucleophiles (furan, pyrrole, and indole). This approach offers a convenient route to ferrocenes containing side chains with different functional groups. The advantages of the method are associated with the use of a catalyst based on iron, which is a nontoxic and readily available transition metal, and in the direct OH substitution, which produces water as the only byproduct.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
