Novel homo-oligomers of the Gly-L-Oxd moiety have been prepared and their preferential conformations have been analyzed by IR, 1H NMR and CD spectroscopy, with the aim of checking whether these molecules are able to fold in ordered structures. We have noticed that in these homo-oligomers two stabilizing effects are active: besides the trans conformation of the imide group, the formation of C=O…H-N hydrogen bonds takes place and is very sensitive to the pseudopeptide size.
Stabilizing Effects in Oxazolidin-2-ones-Containing Pseudopeptides / G. Luppi; C. Soffrè; C. Tomasini. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 15:(2004), pp. 1645-1650. [10.1016/j.tetasy.2004.03.033]
Stabilizing Effects in Oxazolidin-2-ones-Containing Pseudopeptides
LUPPI, GIANLUIGI;TOMASINI, CLAUDIA
2004
Abstract
Novel homo-oligomers of the Gly-L-Oxd moiety have been prepared and their preferential conformations have been analyzed by IR, 1H NMR and CD spectroscopy, with the aim of checking whether these molecules are able to fold in ordered structures. We have noticed that in these homo-oligomers two stabilizing effects are active: besides the trans conformation of the imide group, the formation of C=O…H-N hydrogen bonds takes place and is very sensitive to the pseudopeptide size.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
