With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.

Development of New Calcium Receptors Based on Oxazolidin-2-ones Containing Pseudopeptides

LUPPI, GIANLUIGI;GARELLI, ANDREA;PRODI, LUCA;TOMASINI, CLAUDIA
2005

Abstract

With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
G. Luppi; A. Garelli; L. Prodi; Q. B. Broxterman; B. Kaptein; C. Tomasini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/18734
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