With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
G. Luppi, A. Garelli, L. Prodi, Q. B. Broxterman, B. Kaptein, C. Tomasini (2005). Development of New Calcium Receptors Based on Oxazolidin-2-ones Containing Pseudopeptides. ORGANIC & BIOMOLECULAR CHEMISTRY, 3, 1520-1524 [10.1039/b501017a].
Development of New Calcium Receptors Based on Oxazolidin-2-ones Containing Pseudopeptides
LUPPI, GIANLUIGI;GARELLI, ANDREA;PRODI, LUCA;TOMASINI, CLAUDIA
2005
Abstract
With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
