A novel application of solid acid catalysts in the chemoselective Friedel-Crafts (FC) alkylation of indoles is reported. The optimal protocol allows highly functionalized indolyl compds. to be synthesized in excellent yields through conjugate addn. of indoles with a,b-unsatd. ketones and nitro compds. Finally, the use of com. Amberlyst-15 as the heterogeneous catalyst for highly atom efficient continuous and semicontinuous Friedel-Crafts processes is described.
Titolo: | Solid acids catalysed Michael-type conjugate addition of indoles to electron-poor C-C double bonds: towards high atom economy semi-continuous processes |
Autore/i: | BANDINI, MARCO; M. FAGIOLI; UMANI RONCHI, ACHILLE |
Autore/i Unibo: | |
Anno: | 2004 |
Rivista: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/adsc.200303213 |
Abstract: | A novel application of solid acid catalysts in the chemoselective Friedel-Crafts (FC) alkylation of indoles is reported. The optimal protocol allows highly functionalized indolyl compds. to be synthesized in excellent yields through conjugate addn. of indoles with a,b-unsatd. ketones and nitro compds. Finally, the use of com. Amberlyst-15 as the heterogeneous catalyst for highly atom efficient continuous and semicontinuous Friedel-Crafts processes is described. |
Data prodotto definitivo in UGOV: | 2005-10-18 14:23:02 |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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