A review. After more than 125 yr, the Friedel-Crafts alkylation is still one of the most studied and most utilized reactions in org. synthesis. What is the secret of this astonishing success Perhaps the great versatility in; scope and applicability continues to justify its crucial role in the synthesis of more and more complex mols. However, it has taken more than a century for asym. catalytic versions of this reaction to be developed and subsequently extended to a range of arom. compds. and alkylating agents. Herein recent developments in the design and use of catalytic and stereoselective strategies for the alkylation of arom. systems and synthesis of a wide range of polyfunctionalized enantiomerically enriched compds. were reviewed.

New Catalytic Approaches in the Enantioselective Friedel-Crafts Alkylation Reaction

BANDINI, MARCO;MELLONI, ALFONSO;UMANI RONCHI, ACHILLE
2004

Abstract

A review. After more than 125 yr, the Friedel-Crafts alkylation is still one of the most studied and most utilized reactions in org. synthesis. What is the secret of this astonishing success Perhaps the great versatility in; scope and applicability continues to justify its crucial role in the synthesis of more and more complex mols. However, it has taken more than a century for asym. catalytic versions of this reaction to be developed and subsequently extended to a range of arom. compds. and alkylating agents. Herein recent developments in the design and use of catalytic and stereoselective strategies for the alkylation of arom. systems and synthesis of a wide range of polyfunctionalized enantiomerically enriched compds. were reviewed.
M. BANDINI; A. MELLONI; UMANI RONCHI A.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1854
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 698
  • ???jsp.display-item.citation.isi??? 678
social impact