In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.
Click Chemistry on the Surface of PLGA-b-PEG Polymeric Nanoparticles: A Novel Targetable Fluorescent Imaging Nanocarrier / Andrea Pucci; Erica Locatelli; Jessica Ponti; Chiara Uboldi; Valerio Molinari; Mauro Comes Franchini. - In: JOURNAL OF NANOPARTICLE RESEARCH. - ISSN 1388-0764. - STAMPA. - 15:(2013), pp. 1818-1823. [10.1007/s11051-013-1818-8]
Click Chemistry on the Surface of PLGA-b-PEG Polymeric Nanoparticles: A Novel Targetable Fluorescent Imaging Nanocarrier
LOCATELLI, ERICA;COMES FRANCHINI, MAURO
2013
Abstract
In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
