In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.
Andrea Pucci, Erica Locatelli, Jessica Ponti, Chiara Uboldi, Valerio Molinari, Mauro Comes Franchini (2013). Click Chemistry on the Surface of PLGA-b-PEG Polymeric Nanoparticles: A Novel Targetable Fluorescent Imaging Nanocarrier. JOURNAL OF NANOPARTICLE RESEARCH, 15, 1818-1823 [10.1007/s11051-013-1818-8].
Click Chemistry on the Surface of PLGA-b-PEG Polymeric Nanoparticles: A Novel Targetable Fluorescent Imaging Nanocarrier
LOCATELLI, ERICA;COMES FRANCHINI, MAURO
2013
Abstract
In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
