Efron's (1971) Biased Coin Design is a well-known randomization technique that helps neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the BCD have been proposed by several authors, who have focused mainly on the large sample properties of their designs. We modify Efron's procedure by introducing an Adjustable Biased Coin Design (ABCD), more flexible than his. We compare it to other existing coin designs; in terms of balance and lack of predictability, its performance for small samples appears in many cases to be an improvement with respect to the other sequential randomized allocation procedures
BALDI ANTOGNINI, A., Giovagnoli, A. (2004). A new 'biased coin design' for the sequential allocation of two treatments. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, 53(4), 651-664.
A new 'biased coin design' for the sequential allocation of two treatments
BALDI ANTOGNINI, ALESSANDRO;GIOVAGNOLI, ALESSANDRA
2004
Abstract
Efron's (1971) Biased Coin Design is a well-known randomization technique that helps neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the BCD have been proposed by several authors, who have focused mainly on the large sample properties of their designs. We modify Efron's procedure by introducing an Adjustable Biased Coin Design (ABCD), more flexible than his. We compare it to other existing coin designs; in terms of balance and lack of predictability, its performance for small samples appears in many cases to be an improvement with respect to the other sequential randomized allocation proceduresI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
