A group of sporadic breast carcinomas, with no alteration in TP53 locus, were analysed for the presence of LOH in 17p13.3, distinct from and telomeric to TP53. LOH by at least one marker were observed in 13 of 47 informative cases (27,6%). Clinico-pathological parameters of the patients were evaluated. LOH at distal 17p13.3 did significantly correlate with the absence of oestrogen receptors (ER) (P=0.018), progesterone receptors (PgR) (P= 0.009) and concordant absence of either ER or PgR (P=0.006). This may provide a basis for speculation as to the function of the putative tumour suppressor genes in 17p13.pter in sporadic breast cancer.
RONCUZZI L, BROGNARA I, BAIOCCHI D, AMADORI D, GASPERI CAMPANI A. (2005). Loss of heterozygosity at 17p13.3-ter, distal to TP 53, correlates with negative hormonal phenotype in sporadic breast cancer. ONCOLOGY REPORTS, 14, 471-474.
Loss of heterozygosity at 17p13.3-ter, distal to TP 53, correlates with negative hormonal phenotype in sporadic breast cancer
RONCUZZI, LAURA;BAIOCCHI, DANIELA;GASPERI CAMPANI, ANNA
2005
Abstract
A group of sporadic breast carcinomas, with no alteration in TP53 locus, were analysed for the presence of LOH in 17p13.3, distinct from and telomeric to TP53. LOH by at least one marker were observed in 13 of 47 informative cases (27,6%). Clinico-pathological parameters of the patients were evaluated. LOH at distal 17p13.3 did significantly correlate with the absence of oestrogen receptors (ER) (P=0.018), progesterone receptors (PgR) (P= 0.009) and concordant absence of either ER or PgR (P=0.006). This may provide a basis for speculation as to the function of the putative tumour suppressor genes in 17p13.pter in sporadic breast cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
