Real-time three-dimensional echocardiographic (RT3DE) datasets contain dynamic volumetric information on cardiac function. However, quantification of left ventricular (LV) function from 3D echocardiographic data is performed on cut-planes extracted from the 3D datasets and thus does not fully exploit the volumetric information. Accordingly, we developed a volumetric analysis technique aimed at quantification of global and regional LV function. Methods and Results. RT3DE images obtained in 30 patients (Philips 7500) were analyzed using custom software based on level-set approach for semi-automated detection of LV endocardial surface throughout the cardiac cycle, from which global and regional LV volume (LVV) and wall motion (WM) time-curves were obtained. Study design included three protocols. In protocol 1, time-curves obtained in 16 patients were compared point-by-point with magnetic resonance (MR) data (linear regression and Bland-Altman analyses). Global LVV correlated highly with MR (r=0.98; y=0.99x+2.3) with minimal bias (1.4ml) and narrow limits of agreement (±20ml). WM correlated highly only in basal and mid-ventricular segments (r=0.88; y=0.85x+0.7). In protocol 2, we tested the ability of this technique to differentiate populations with known differences in LV function by studying 9 patients with dilated cardiomyopathy and 9 normal subjects. All calculated indices of global and regional systolic and diastolic LV function were significantly different between the groups. In protocol 3, we tested the feasibility of automated detection of regional WM abnormalities in 11 patients. In each segment, abnormality was detected when regional shortening fraction was below a threshold obtained in normal subjects. The automated detection agreed with expert interpretation of 2D WM in 86% segments. Conclusion. Volumetric analysis of RT3DE data is clinically feasible and allows fast, semi-automated, dynamic measurement of LVV and automated detection of regional wall motion abnormalities.

Volumetric quantification of global and regional left ventricular function from real-time three-dimensional echocardiographic images / C. Corsi; R. M. Lang; F. Veronesi; L. Weinert; E. G. Caiani; P. MacEneaney; C. Lamberti; V. Mor-Avi. - In: CIRCULATION. - ISSN 0009-7322. - STAMPA. - 112:(2005), pp. 1161-1170. [10.1161/CIRCULATIONAHA.104.513689]

Volumetric quantification of global and regional left ventricular function from real-time three-dimensional echocardiographic images

CORSI, CRISTIANA;VERONESI, FEDERICO;LAMBERTI, CLAUDIO;
2005

Abstract

Real-time three-dimensional echocardiographic (RT3DE) datasets contain dynamic volumetric information on cardiac function. However, quantification of left ventricular (LV) function from 3D echocardiographic data is performed on cut-planes extracted from the 3D datasets and thus does not fully exploit the volumetric information. Accordingly, we developed a volumetric analysis technique aimed at quantification of global and regional LV function. Methods and Results. RT3DE images obtained in 30 patients (Philips 7500) were analyzed using custom software based on level-set approach for semi-automated detection of LV endocardial surface throughout the cardiac cycle, from which global and regional LV volume (LVV) and wall motion (WM) time-curves were obtained. Study design included three protocols. In protocol 1, time-curves obtained in 16 patients were compared point-by-point with magnetic resonance (MR) data (linear regression and Bland-Altman analyses). Global LVV correlated highly with MR (r=0.98; y=0.99x+2.3) with minimal bias (1.4ml) and narrow limits of agreement (±20ml). WM correlated highly only in basal and mid-ventricular segments (r=0.88; y=0.85x+0.7). In protocol 2, we tested the ability of this technique to differentiate populations with known differences in LV function by studying 9 patients with dilated cardiomyopathy and 9 normal subjects. All calculated indices of global and regional systolic and diastolic LV function were significantly different between the groups. In protocol 3, we tested the feasibility of automated detection of regional WM abnormalities in 11 patients. In each segment, abnormality was detected when regional shortening fraction was below a threshold obtained in normal subjects. The automated detection agreed with expert interpretation of 2D WM in 86% segments. Conclusion. Volumetric analysis of RT3DE data is clinically feasible and allows fast, semi-automated, dynamic measurement of LVV and automated detection of regional wall motion abnormalities.
2005
Volumetric quantification of global and regional left ventricular function from real-time three-dimensional echocardiographic images / C. Corsi; R. M. Lang; F. Veronesi; L. Weinert; E. G. Caiani; P. MacEneaney; C. Lamberti; V. Mor-Avi. - In: CIRCULATION. - ISSN 0009-7322. - STAMPA. - 112:(2005), pp. 1161-1170. [10.1161/CIRCULATIONAHA.104.513689]
C. Corsi; R. M. Lang; F. Veronesi; L. Weinert; E. G. Caiani; P. MacEneaney; C. Lamberti; V. Mor-Avi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/16213
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