The influence of structural modifications of the diamine ligand and the ZnR2 precursor in the [ZnR2–diamine]-catalyzed asymmetric hydrosilylation of prochiral ketones with PMHS in aprotic medium is reported. A new diamine ligand giving up to 91% ee in the reduction of acetophenone is described. The scope of this reduction system has been investigated using variously functionalized ketones and some deactivation pathways have been identified.
New developments in zinc-catalyzed asymmetric hydrosilylation of ketones with PMHS / V. Bette; A. Mortreux; D. Savoia; J.-F. Carpentier. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 60:(2004), pp. 2837-2842. [10.1016/j.tet.2004.01.051]
New developments in zinc-catalyzed asymmetric hydrosilylation of ketones with PMHS
SAVOIA, DIEGO;
2004
Abstract
The influence of structural modifications of the diamine ligand and the ZnR2 precursor in the [ZnR2–diamine]-catalyzed asymmetric hydrosilylation of prochiral ketones with PMHS in aprotic medium is reported. A new diamine ligand giving up to 91% ee in the reduction of acetophenone is described. The scope of this reduction system has been investigated using variously functionalized ketones and some deactivation pathways have been identified.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
