Transfer of bioactives through epidermis can be viewed as a model of bioavailability for functional cosmetics and is relevant to their efficacy. Nine equivalent O/W emulsions differing in the composition of the lipid phase were comparatively tested for their ability to release vitamin B6 through 18-days-old reconstructed human epidermis, in vitro. Formulations afforded efficient diffusion of the vitamin through the skin, although the actual flux varied considerably, with coefficient of permeability in the range 15.0 – 297.3 10-5cm/h at 34°C. Bioavailability grew in the order: sesame oil < squalane ~ raw wheat germ oil < dibutyladipate ~ polydimethylsiloxane. Addition of 5% w/w free fatty acids (stearic, lauric, caprilyc, and oleic) to lowest performing sesame oil increased the bioavailability by 1.2-fold, 6-fold, 20-fold and 10-fold respectively.

LUCA VALGIMIGLI, SIMONE GABBANINI, GIULIA ARNIANI, ELENA LUCCHI (2013). Influence of the lipid-phase composition on the trans-epidermal transfer of vitamin B6 from O/W emulsions. HOUSEHOLD AND PERSONAL CARE TODAY, 8(1), 24-27.

Influence of the lipid-phase composition on the trans-epidermal transfer of vitamin B6 from O/W emulsions

VALGIMIGLI, LUCA;
2013

Abstract

Transfer of bioactives through epidermis can be viewed as a model of bioavailability for functional cosmetics and is relevant to their efficacy. Nine equivalent O/W emulsions differing in the composition of the lipid phase were comparatively tested for their ability to release vitamin B6 through 18-days-old reconstructed human epidermis, in vitro. Formulations afforded efficient diffusion of the vitamin through the skin, although the actual flux varied considerably, with coefficient of permeability in the range 15.0 – 297.3 10-5cm/h at 34°C. Bioavailability grew in the order: sesame oil < squalane ~ raw wheat germ oil < dibutyladipate ~ polydimethylsiloxane. Addition of 5% w/w free fatty acids (stearic, lauric, caprilyc, and oleic) to lowest performing sesame oil increased the bioavailability by 1.2-fold, 6-fold, 20-fold and 10-fold respectively.
2013
LUCA VALGIMIGLI, SIMONE GABBANINI, GIULIA ARNIANI, ELENA LUCCHI (2013). Influence of the lipid-phase composition on the trans-epidermal transfer of vitamin B6 from O/W emulsions. HOUSEHOLD AND PERSONAL CARE TODAY, 8(1), 24-27.
LUCA VALGIMIGLI; SIMONE GABBANINI; GIULIA ARNIANI; ELENA LUCCHI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/154895
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