Periungual pyogenic granuloma following imatinib therapy in a patient with chronic myelogenous leukemia.

Pyogenic granuloma is a benign, rapidly growing, acquired vascular tumor, usually presenting as a sessile or polypoid nodule that can often bleed or ulcerate. It is commonly located on the skin of the trunk and the extremities, but it can also originate from the mucous membranes. It may rarely be subcutaneous or intravascular. It typically appears as a red papule or nodule, and it frequently involves the nail, including the nail bed and the periungual tissues. Its etiology and pathogenesis are not completely understood. The condition may be either idiopathic, or it may occur after acute and chronic traumas, during pregnancy, because of inflammatory systemic diseases, or because of the administration of some systemic medications.1 Drug-induced pyogenic granulomas have been frequently reported; the most frequently involved drugs are likely to be retinoids, antiretroviral agents, and antitumoral drugs.1 In particular, among the latter, epidermal growth factor receptor inhibitors