Immunosuppressive agents are the standard therapeutic approach for immune thrombocy-topenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action alternative to immunosuppression, like thrombopoietin receptor agonists (TRAs), may find particular indication. We report the unique case of a patient with severe immunodeficiency and ITP, who experienced a serious infectious complication while on steroids treatment, and who was successfully treated with Romiplostim second-line. The present experience supports the effectiveness and safety of TRAs as early treatment of ITP patients with drug-induced immunodeficiency or with active infections.
Francesca Palandri, Nicola Polverelli, Francesca Lifrieri, Lucia Catani, Maria Benedetta Giannini, Michele Baccarani, et al. (2012). Romiplostim as early treatment of immune thrombocytopenia with severe immunodeficiency. HEMATOLOGY REPORTS, 4(2), 1-2 [10.4081/hr.2012.e10].
Romiplostim as early treatment of immune thrombocytopenia with severe immunodeficiency
PALANDRI, FRANCESCA;POLVERELLI, NICOLA;CATANI, LUCIA;BACCARANI, MICHELE;VIANELLI, NICOLA
2012
Abstract
Immunosuppressive agents are the standard therapeutic approach for immune thrombocy-topenia (ITP). Their prolonged use may increase the risk of infectious complications, particularly when the patient is already at higher infectious risk. In this setting, the use of drugs with a mechanism of action alternative to immunosuppression, like thrombopoietin receptor agonists (TRAs), may find particular indication. We report the unique case of a patient with severe immunodeficiency and ITP, who experienced a serious infectious complication while on steroids treatment, and who was successfully treated with Romiplostim second-line. The present experience supports the effectiveness and safety of TRAs as early treatment of ITP patients with drug-induced immunodeficiency or with active infections.File | Dimensione | Formato | |
---|---|---|---|
4101-Article Text-28335-2-10-20120626.pdf
accesso aperto
Tipo:
Versione (PDF) editoriale
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione
302.7 kB
Formato
Adobe PDF
|
302.7 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.