Polycystic ovary syndrome (PCOS) recently has been identified as a risk factor associated with type 2 diabetes. However, the evidence derives from cross-sectional observational studies, retrospective studies, or short-term prospective studies. This long-term prospective study of a large cohort of women with PCOS, followed from youth to middle age, aimed at estimating, for the first time, the incidence and potential predictors of type 2 diabetes in this population. A total of 255 women with PCOS were followed for at least 10 years (mean follow-up 16.9 years). Six women were patients with diabetes at baseline, and another 42 women developed type 2 diabetes during the follow-up. The incidence rate of type 2 diabetes in the study population was 1.05 per 100 person-years. The age-standardized prevalence of diabetes at the end of follow-up was 39.3%, which is significantly higher with respect to that of the general Italian female population of a similar age (5.8%). The likelihood of developing type 2 diabetes significantly increased as BMI, fasting glucose, and glucose area under the curve at baseline increased and significantly decreased as sex hormone-binding globulin (SHBG) levels at follow-up increased. This study demonstrates that the risk of type 2 diabetes is markedly elevated in middle-aged women with PCOS and suggests including BMI, glucose, and SHBG-circulating levels in the risk stratification.

Gambineri A, Patton L, Altieri P, Pagotto U, Pizzi C, Manzoli L, et al. (2012). Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study. DIABETES, 61(9), 2369-2374 [10.2337/db11-1360].

Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study.

GAMBINERI, ALESSANDRA;PATTON, LAURA;ALTIERI, PAOLA;PAGOTTO, UBERTO;PIZZI, CARMINE;Manzoli L;PASQUALI, RENATO
2012

Abstract

Polycystic ovary syndrome (PCOS) recently has been identified as a risk factor associated with type 2 diabetes. However, the evidence derives from cross-sectional observational studies, retrospective studies, or short-term prospective studies. This long-term prospective study of a large cohort of women with PCOS, followed from youth to middle age, aimed at estimating, for the first time, the incidence and potential predictors of type 2 diabetes in this population. A total of 255 women with PCOS were followed for at least 10 years (mean follow-up 16.9 years). Six women were patients with diabetes at baseline, and another 42 women developed type 2 diabetes during the follow-up. The incidence rate of type 2 diabetes in the study population was 1.05 per 100 person-years. The age-standardized prevalence of diabetes at the end of follow-up was 39.3%, which is significantly higher with respect to that of the general Italian female population of a similar age (5.8%). The likelihood of developing type 2 diabetes significantly increased as BMI, fasting glucose, and glucose area under the curve at baseline increased and significantly decreased as sex hormone-binding globulin (SHBG) levels at follow-up increased. This study demonstrates that the risk of type 2 diabetes is markedly elevated in middle-aged women with PCOS and suggests including BMI, glucose, and SHBG-circulating levels in the risk stratification.
2012
Gambineri A, Patton L, Altieri P, Pagotto U, Pizzi C, Manzoli L, et al. (2012). Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study. DIABETES, 61(9), 2369-2374 [10.2337/db11-1360].
Gambineri A;Patton L;Altieri P;Pagotto U;Pizzi C;Manzoli L;Pasquali R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/151926
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