All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.
X. Companyó , A. Mazzanti, A. Moyano, A. Janecka, R. Rios (2013). First one-pot organocatalytic synthesis of alpha-methylene - gamma-lactones. CHEMICAL COMMUNICATIONS, 49, 1184-1186 [10.1039/C2CC38659C].
First one-pot organocatalytic synthesis of alpha-methylene - gamma-lactones
MAZZANTI, ANDREA;
2013
Abstract
All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.File in questo prodotto:
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