new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.
M. Bandini, A. Garelli, M. Rovinetti, S. Tommasi, A. Umani-Ronchi (2005). Catalytic enantioselective addition of indoles to aryl-nitroalkenes. Effective route to enantiomerically enriched tryptamine precursors. CHIRALITY, 17, 522-529 [10.1002/chir.20189].
Catalytic enantioselective addition of indoles to aryl-nitroalkenes. Effective route to enantiomerically enriched tryptamine precursors
BANDINI, MARCO;GARELLI, ANDREA;TOMMASI, SIMONA;UMANI RONCHI, ACHILLE
2005
Abstract
new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
