new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.
Catalytic enantioselective addition of indoles to aryl-nitroalkenes. Effective route to enantiomerically enriched tryptamine precursors
BANDINI, MARCO;GARELLI, ANDREA;TOMMASI, SIMONA;UMANI RONCHI, ACHILLE
2005
Abstract
new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.File in questo prodotto:
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