new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.
Catalytic enantioselective addition of indoles to aryl-nitroalkenes. Effective route to enantiomerically enriched tryptamine precursors / M. Bandini; A. Garelli; M. Rovinetti; S. Tommasi; A. Umani-Ronchi. - In: CHIRALITY. - ISSN 0899-0042. - STAMPA. - 17:(2005), pp. 522-529. [10.1002/chir.20189]
Catalytic enantioselective addition of indoles to aryl-nitroalkenes. Effective route to enantiomerically enriched tryptamine precursors
BANDINI, MARCO;GARELLI, ANDREA;TOMMASI, SIMONA;UMANI RONCHI, ACHILLE
2005
Abstract
new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee). (c) 2005 Wiley-Liss, Inc. Chirality 17:522-529, 2005.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.