Four lidocaine molecular salts of dicarboxylic acids (oxalic, fumaric, malonic, and succinic) were synthesized and characterized by a combined use of X-ray power and single-crystal diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy (FT-IR), and solid-state NMR (H-1 MAS and CRAMPS, and C-13 and N-15 CPMAS); all molecular salts show a dramatic increase in their melting point with respect to both lidocaine and lidocaine hydrochloride, and a higher dissolution rate and thermodynamic solubility in physiological solution with respect to the free base.
Molecular Salts of Anesthetic Lidocaine with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study / Dario Braga;Laura Chelazzi;Fabrizia Grepioni;Elena Dichiarante;Michele R. Chierotti;Roberto Gobetto. - In: CRYSTAL GROWTH & DESIGN. - ISSN 1528-7483. - STAMPA. - 13:(2013), pp. 2564-2572. [10.1021/cg400331h]
Molecular Salts of Anesthetic Lidocaine with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study
BRAGA, DARIO;CHELAZZI, LAURA;GREPIONI, FABRIZIA;
2013
Abstract
Four lidocaine molecular salts of dicarboxylic acids (oxalic, fumaric, malonic, and succinic) were synthesized and characterized by a combined use of X-ray power and single-crystal diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy (FT-IR), and solid-state NMR (H-1 MAS and CRAMPS, and C-13 and N-15 CPMAS); all molecular salts show a dramatic increase in their melting point with respect to both lidocaine and lidocaine hydrochloride, and a higher dissolution rate and thermodynamic solubility in physiological solution with respect to the free base.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
