BACKGROUND AND AIMS: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS: 86 acutely psychotic patients treated with haloperidol were studied. RESULTS: A PANSS reduction ≤16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction ≥23% at 1 week of treatment predicts response at 3 weeks, with a specificity of 84% and a sensitivity of 86%. CONCLUSION: Our results confirm that an early response to antipsychotic treatment accurately predicts the treatment effectiveness and extends it to a prediction performed as early as 1 week.
Antipsychotic response in the first week predicts later efficacy. Giegling I, Porcelli S, Balzarro B, Andrisano C, Schäfer M, Möller HJ, et al. (2012). Antipsychotic response in the first week predicts later efficacy. NEUROPSYCHOBIOLOGY, 66, 100-105 [10.1159/000337739.].
Antipsychotic response in the first week predicts later efficacy.
SERRETTI, ALESSANDRO
2012
Abstract
BACKGROUND AND AIMS: Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS: 86 acutely psychotic patients treated with haloperidol were studied. RESULTS: A PANSS reduction ≤16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). Conversely, a PANSS reduction ≥23% at 1 week of treatment predicts response at 3 weeks, with a specificity of 84% and a sensitivity of 86%. CONCLUSION: Our results confirm that an early response to antipsychotic treatment accurately predicts the treatment effectiveness and extends it to a prediction performed as early as 1 week.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
