Quinoxaline and dihydropyrazine derivatives were obtained in high yields by simple addition 1,2-diamines and 1,2-dicarbonyl compounds in water. In some cases, the products spontaneously precipitates from the reaction mixture, making it possible to recover and reuse the mother liquor for further condensations. The very mild reaction conditions, the high yields of the products and the absence of any catalyst make this methodology an efficient and green route to quinoxalines and dihydropyrazines.
Camilla Delpivo, Gabriele Micheletti, Carla Boga (2013). A green synthesis of quinoxalines and 2,3-dihydropyrazines. SYNTHESIS, 45, 1546-1552 [10.1055/s-0033-1338441].
A green synthesis of quinoxalines and 2,3-dihydropyrazines
DELPIVO, CAMILLA;MICHELETTI, GABRIELE;BOGA, CARLA
2013
Abstract
Quinoxaline and dihydropyrazine derivatives were obtained in high yields by simple addition 1,2-diamines and 1,2-dicarbonyl compounds in water. In some cases, the products spontaneously precipitates from the reaction mixture, making it possible to recover and reuse the mother liquor for further condensations. The very mild reaction conditions, the high yields of the products and the absence of any catalyst make this methodology an efficient and green route to quinoxalines and dihydropyrazines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
