Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours

Ferreira J.A., Videira P.A., Lima L., Pereira S., Silva M., Carrascal M., et al. (2013). Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours. MOLECULAR ONCOLOGY, 7, 719-731 [10.1016/j.molonc.2013.03.001].

Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours

SEVERINO, PAULO;DALL'OLIO, FABIO;
2013

Abstract

Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours
2013
Ferreira J.A., Videira P.A., Lima L., Pereira S., Silva M., Carrascal M., et al. (2013). Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours. MOLECULAR ONCOLOGY, 7, 719-731 [10.1016/j.molonc.2013.03.001].
Ferreira J.A.; Videira P.A.; Lima L.; Pereira S.; Silva M.; Carrascal M.; Severino P.F.; Fernandes E.; Almeida A.; Costa C.; Vitorino R.; Amaro T.; Ol...espandi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/139799
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 41
  • Scopus 76
  • ???jsp.display-item.citation.isi??? 74
social impact