The electron beam emitted backward by Plasma Focus devices is being considered as a radiation source for IORT applications. Radiobiological investigations have been conducted to assess the potential of this new prototype of IORT device. A standard Xray beam ISO-H60 was used for comparison, irradiating cell cultures in a holder filled with an aqueous solution. The influence of scattering by the culture water and by the walls of the holder was investigated to determine its influence on the dose delivered to the cell culture. MCNPX simulations were run and experimental measurements conducted. The effect of scattering by the holder was found to be negligible; scattering by the culture water was determined to give an increase in dose of the order of 10%.
E. Ceccolini, P. Ferrari, D.M. Castelluccio, D. Mostacci, M. Sumini (2013). The effect of scattering by water on the irradiation of cell cultures for the dosimetric characterization of a new prototype of IORT (Intra-Operative Radiation Therapy) device: Monte Carlo simulation and experimental validation. HEALTH PHYSICS, 105(4), 374-378 [10.1097/HP.0b013e318295733f].
The effect of scattering by water on the irradiation of cell cultures for the dosimetric characterization of a new prototype of IORT (Intra-Operative Radiation Therapy) device: Monte Carlo simulation and experimental validation
MOSTACCI, DOMIZIANO;SUMINI, MARCO
2013
Abstract
The electron beam emitted backward by Plasma Focus devices is being considered as a radiation source for IORT applications. Radiobiological investigations have been conducted to assess the potential of this new prototype of IORT device. A standard Xray beam ISO-H60 was used for comparison, irradiating cell cultures in a holder filled with an aqueous solution. The influence of scattering by the culture water and by the walls of the holder was investigated to determine its influence on the dose delivered to the cell culture. MCNPX simulations were run and experimental measurements conducted. The effect of scattering by the holder was found to be negligible; scattering by the culture water was determined to give an increase in dose of the order of 10%.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
