Pax8 is a transcription facto expressed in embryonal human tissues, in particular in the developing thyroid gland, kidney, Müllerian structures, and nervous system (e.g. otic placode), and in the human placenta. During thyroid development PAX8 is expressed in the thyroid anlage. During kidney development it is expressed in the Sshaped body and in the early proximal tube, but is absent in the uretic bud and condensing mesenchyme. In the adult Pax8 is expressed in the thyroid gland and kidney but it is absent in most other developed organs. Pax8 expression has been described in several tumor types including thyroid and ovarian carcinomas and Wilms' tumor.
PAX8 (paired box 8)
DE BIASE, DARIO;MORANDI, LUCA;TALLINI, GIOVANNI
2010
Abstract
Pax8 is a transcription facto expressed in embryonal human tissues, in particular in the developing thyroid gland, kidney, Müllerian structures, and nervous system (e.g. otic placode), and in the human placenta. During thyroid development PAX8 is expressed in the thyroid anlage. During kidney development it is expressed in the Sshaped body and in the early proximal tube, but is absent in the uretic bud and condensing mesenchyme. In the adult Pax8 is expressed in the thyroid gland and kidney but it is absent in most other developed organs. Pax8 expression has been described in several tumor types including thyroid and ovarian carcinomas and Wilms' tumor.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
