For clinical trials that compare two or more competing treatments, the literature proposes several randomizat ion rules that aim at favouring, at each stage of the trial, the treatment that appears to be best. In two papers the present authors have suggested criteria of optimal allocation that combine inferential precision and ethical gain by means of flexible weights, in order to achieve a good trade-off between efficiency and ethical concerns. The ensuing optimal allocation of the treatments can be targeted by a suitable response-adaptive randomization rule. The purpose of this paper is to illustrate and extend the results previously obtained by the authors to a wider range of statistical models for comparative trials. Methods for implementing these designs are given. Some numerical examples are included in order to enhance the applicability.

A. Baldi Antognini, A. Giovagnoli, M. Zagoraiou (2012). Some recent developments in the design of adaptive clinical trials. STATISTICA, 72(4), 375-393 [10.6092/issn.1973-2201/3653].

Some recent developments in the design of adaptive clinical trials

BALDI ANTOGNINI, ALESSANDRO;GIOVAGNOLI, ALESSANDRA;ZAGORAIOU, MAROUSSA
2012

Abstract

For clinical trials that compare two or more competing treatments, the literature proposes several randomizat ion rules that aim at favouring, at each stage of the trial, the treatment that appears to be best. In two papers the present authors have suggested criteria of optimal allocation that combine inferential precision and ethical gain by means of flexible weights, in order to achieve a good trade-off between efficiency and ethical concerns. The ensuing optimal allocation of the treatments can be targeted by a suitable response-adaptive randomization rule. The purpose of this paper is to illustrate and extend the results previously obtained by the authors to a wider range of statistical models for comparative trials. Methods for implementing these designs are given. Some numerical examples are included in order to enhance the applicability.
2012
A. Baldi Antognini, A. Giovagnoli, M. Zagoraiou (2012). Some recent developments in the design of adaptive clinical trials. STATISTICA, 72(4), 375-393 [10.6092/issn.1973-2201/3653].
A. Baldi Antognini; A. Giovagnoli; M. Zagoraiou
File in questo prodotto:
File Dimensione Formato  
Statistica4_12pp.375-393.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 333.78 kB
Formato Adobe PDF
333.78 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/134626
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact