The first example of a catalytic asymmetric vinylogous Povarov reaction is presented. 1-N-Acylamino-1,3-butadienes react selectively at their terminal double bond in the presence of a chiral phosphoric acid catalyst, delivering highly enantioenriched 1,2,3,4- tetrahydroquinolines bearing a synthetically versatile enecarbamate group at the 4-position.
L. Caruana, M. Fochi, S. Ranieri, A. Mazzanti, L. Bernardi (2013). Catalytic highly enantioselective vinylogous Povarov reaction. CHEMICAL COMMUNICATIONS, 49, 880-882 [10.1039/c2cc38002a].
Catalytic highly enantioselective vinylogous Povarov reaction
CARUANA, LORENZO;FOCHI, MARIAFRANCESCA;RANIERI, SILVIA;MAZZANTI, ANDREA;BERNARDI, LUCA
2013
Abstract
The first example of a catalytic asymmetric vinylogous Povarov reaction is presented. 1-N-Acylamino-1,3-butadienes react selectively at their terminal double bond in the presence of a chiral phosphoric acid catalyst, delivering highly enantioenriched 1,2,3,4- tetrahydroquinolines bearing a synthetically versatile enecarbamate group at the 4-position.File in questo prodotto:
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