Best of both worlds: Organocatalytic SN1-type reactions promoted by indium(III) salts were performed with activated benzylic and benzhydrylic substrates. High ee values and moderate diastereomeric ratios were obtained. The presence of a 4-NMe2Ph group, which is useful for further transformations, is essential for obtaining high yields. The synergy of indium(III) salts with organocatalysis is a useful strategy for stereoselective transformations.
Indium(III)-Promoted Organocatalytic Enantioselective α-Alkylation of Aldehydes with Benzylic and Benzhydrylic Alcohols / M. Guiteras Capdevila; E. Emer; F. Benfatti; A. Gualandi; C. M. Wilson; P. G. Cozzi. - In: ASIAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 2193-5815. - STAMPA. - 1:(2012), pp. 38-42. [10.1002/ajoc.201200013]
Indium(III)-Promoted Organocatalytic Enantioselective α-Alkylation of Aldehydes with Benzylic and Benzhydrylic Alcohols
EMER, ENRICO;BENFATTI, FIDES;GUALANDI, ANDREA;COZZI, PIER GIORGIO
2012
Abstract
Best of both worlds: Organocatalytic SN1-type reactions promoted by indium(III) salts were performed with activated benzylic and benzhydrylic substrates. High ee values and moderate diastereomeric ratios were obtained. The presence of a 4-NMe2Ph group, which is useful for further transformations, is essential for obtaining high yields. The synergy of indium(III) salts with organocatalysis is a useful strategy for stereoselective transformations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
