Best of both worlds: Organocatalytic SN1-type reactions promoted by indium(III) salts were performed with activated benzylic and benzhydrylic substrates. High ee values and moderate diastereomeric ratios were obtained. The presence of a 4-NMe2Ph group, which is useful for further transformations, is essential for obtaining high yields. The synergy of indium(III) salts with organocatalysis is a useful strategy for stereoselective transformations.
Indium(III)-Promoted Organocatalytic Enantioselective α-Alkylation of Aldehydes with Benzylic and Benzhydrylic Alcohols
EMER, ENRICO;BENFATTI, FIDES;GUALANDI, ANDREA;COZZI, PIER GIORGIO
2012
Abstract
Best of both worlds: Organocatalytic SN1-type reactions promoted by indium(III) salts were performed with activated benzylic and benzhydrylic substrates. High ee values and moderate diastereomeric ratios were obtained. The presence of a 4-NMe2Ph group, which is useful for further transformations, is essential for obtaining high yields. The synergy of indium(III) salts with organocatalysis is a useful strategy for stereoselective transformations.File in questo prodotto:
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