The rationale underlying probiotics use in the treatment of IBD is based on compelling evidence that intestinal bacteria have a role in disease pathogenesis. The distal ileum and the colon are the areas with the highest bacterial concentrations and are also the sites of inflammation in IBD. Similarly, pouchitis, the nonspecific inflammation of the ileal reservoir that can occur after ileo-anal anastomosis, appears to be associated with bacterial overgrowth and dysbiosis. Enteric bacteria and their products have also been found within the inflamed mucosa of patients with Crohn’s disease
Probiotics in IBD: A critical review
GIONCHETTI, PAOLO;CALABRESE, CARLO;TAMBASCO, ROSY;STRAFORINI, GIULIA;BRUGNERA, RAMONA;LIGUORI, GIUSEPPINA;RIZZELLO, FERNANDO
2010
Abstract
The rationale underlying probiotics use in the treatment of IBD is based on compelling evidence that intestinal bacteria have a role in disease pathogenesis. The distal ileum and the colon are the areas with the highest bacterial concentrations and are also the sites of inflammation in IBD. Similarly, pouchitis, the nonspecific inflammation of the ileal reservoir that can occur after ileo-anal anastomosis, appears to be associated with bacterial overgrowth and dysbiosis. Enteric bacteria and their products have also been found within the inflamed mucosa of patients with Crohn’s diseaseFile in questo prodotto:
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