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EnglishMechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.
| Titolo: | Combining piracetam and lithium salts: ionic co-crystals and co-drugs? | |
| Autore/i: | BRAGA, DARIO; GREPIONI, FABRIZIA; MAINI, LUCIA; D. Capucci; NANNA, SAVERIO; J. Wouters; L. Aerts; L. Queré | |
| Autore/i Unibo: | ||
| Anno: | 2012 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c2cc33855f | |
| Abstract: | Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products. | |
| Data prodotto definitivo in UGOV: | 2013-06-17 11:15:13 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/129340
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