Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.
D. Braga, F. Grepioni, L. Maini, D. Capucci, S. Nanna, J. Wouters, et al. (2012). Combining piracetam and lithium salts: ionic co-crystals and co-drugs?. CHEMICAL COMMUNICATIONS, 48, 8219-8221 [10.1039/c2cc33855f].
Combining piracetam and lithium salts: ionic co-crystals and co-drugs?
BRAGA, DARIO;GREPIONI, FABRIZIA;MAINI, LUCIA;NANNA, SAVERIO;
2012
Abstract
Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
