Background: Subungual squamous cell carcinoma (SSCC) is the most common malignancy of the nail unit. Mohs micrographic surgery (MMS) is a microscopically controlled surgical technique that has a high cure rate for skin cancers despite allowing narrow surgical margins. Objective:  We sought to evaluate the long-term effectiveness of MMS in the treatment of SSCC, and in particular its ability to reduce the number of digital amputations. Methods:Fifteen patients diagnosed with SSCC were treated with MMS as the first-line surgical approach, and were followed up for between 2 and 5 years. Results:  SSCC was completely excised in 13 patients, while 2 patients required amputation of the distal phalanx. For tumors with predominantly exophytic growth, clinical and radiological findings were found not to be reliable indicators of bone invasion. No recurrences were detected on follow-up. Conclusions: Our results show that MMS provides a high cure rate for SSCC and reduces the number of amputations needed. MMS should become the first-line surgical approach for SSCC.
Dika E., Piraccini B.M., Balestri R., Vaccari S., Misciali C., Patrizi A., et al. (2012). Mohs Surgery for Squamous Cell Carcinoma of the Nail: report of 15 cases. Our Experience and a Long-term Follow Up. BRITISH JOURNAL OF DERMATOLOGY, 167(6), 1310-1314 [10.1111/j.1365-2133.2012.11129.x].
Mohs Surgery for Squamous Cell Carcinoma of the Nail: report of 15 cases. Our Experience and a Long-term Follow Up.
DIKA, EMI;PIRACCINI, BIANCA MARIA;BALESTRI, RICCARDO;VACCARI, SABINA;MISCIALI, COSIMO;PATRIZI, ANNALISA;FANTI, PIER ALESSANDRO
2012
Abstract
Background: Subungual squamous cell carcinoma (SSCC) is the most common malignancy of the nail unit. Mohs micrographic surgery (MMS) is a microscopically controlled surgical technique that has a high cure rate for skin cancers despite allowing narrow surgical margins. Objective: We sought to evaluate the long-term effectiveness of MMS in the treatment of SSCC, and in particular its ability to reduce the number of digital amputations. Methods:Fifteen patients diagnosed with SSCC were treated with MMS as the first-line surgical approach, and were followed up for between 2 and 5 years. Results: SSCC was completely excised in 13 patients, while 2 patients required amputation of the distal phalanx. For tumors with predominantly exophytic growth, clinical and radiological findings were found not to be reliable indicators of bone invasion. No recurrences were detected on follow-up. Conclusions: Our results show that MMS provides a high cure rate for SSCC and reduces the number of amputations needed. MMS should become the first-line surgical approach for SSCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
