This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridisation effect is monitored by means of a Charge Sensitive Amplifier (CSA) and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensor
D. De venuto, B. Riccò (2010). High Resolution Read-Out Circuit for DNA Label-Free Detection System. INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, 4(3), 211-231 [10.1504/IJBET.2010.034940].
High Resolution Read-Out Circuit for DNA Label-Free Detection System
DE VENUTO, DANIELA;RICCO', BRUNO
2010
Abstract
This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridisation effect is monitored by means of a Charge Sensitive Amplifier (CSA) and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensorI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
