This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.
High Resolution Read-Out Circuit for DNA Label-Free Detection System / D. De Venuto; B. Riccò. - STAMPA. - (2008), pp. 4479824.708-4479824.711. (Intervento presentato al convegno IEEE 9th International Symposium on Quality Electronic Design (ISQED 2008) tenutosi a San José, CA nel 17-18 March 2008) [10.1109/ISQED.2008.4479824].
High Resolution Read-Out Circuit for DNA Label-Free Detection System
RICCO', BRUNO
2008
Abstract
This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
