We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2(del)) in 20/418 cases (4.7%). TET2(del) was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2(del) was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2(del) occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).
FISH analysis reveals frequent co-occurence of 4q24/TET2 and 5q and/or 7q deletions / La Starza R.; Crescenzi B.; Nofrini V.; Barba G.; Matteucci C.; Brandimarte L.; Pierini V.; Testoni N.; Musto P.; Paolini S.; Gianfelici V.; Storlazzi C.T.; Pierini A.; Berchicci L.; Gorello P.; Mecucci C.. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 36:(2012), pp. 37-41. [10.1016/j.leukres.2011.08.004]
FISH analysis reveals frequent co-occurence of 4q24/TET2 and 5q and/or 7q deletions
TESTONI, NICOLETTA;PAOLINI, STEFANIA;
2012
Abstract
We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2(del)) in 20/418 cases (4.7%). TET2(del) was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2(del) was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2(del) occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
