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EnglishA key issue when analyzing the biological effects of ionizing radiation is the selection of the biological endpoints. In this study we evaluated the effects of X-rays and protons on membrane ionic currents, cell growth and stress response. The membrane ionic currents amplitude showed a significant nonlinear effects. Growth curves showed a significant dose dependent decrease in the proliferation rate. The fluorescence data suggest a trend in which superoxide intracellular concentration decreases at lower irradiation doses compared to control and higher doses. These results are consistent with a signal transduction pathway where the concentration of superoxide is controlled by type and dose of ionizing radiation
| Titolo: | A system biology approach to ionizing radiation response by mammalian cell lines |
| Autore/i: | VIRELLI, ANGELA; GAVOCI, ENTELE; CASTELLANI, GASTONE; ZIRONI, ISABELLA; CECCOLINI, ELISA; ROCCHI, FEDERICO; SUMINI, MARCO; E. Belligotti |
| Autore/i Unibo: | |
| Anno: | 2011 |
| Titolo del libro: | Proceedings of the SysBioHealth Symposium 2011 |
| Pagina iniziale: | 99 |
| Pagina finale: | 104 |
| Abstract: | A key issue when analyzing the biological effects of ionizing radiation is the selection of the biological endpoints. In this study we evaluated the effects of X-rays and protons on membrane ionic currents, cell growth and stress response. The membrane ionic currents amplitude showed a significant nonlinear effects. Growth curves showed a significant dose dependent decrease in the proliferation rate. The fluorescence data suggest a trend in which superoxide intracellular concentration decreases at lower irradiation doses compared to control and higher doses. These results are consistent with a signal transduction pathway where the concentration of superoxide is controlled by type and dose of ionizing radiation |
| Data prodotto definitivo in UGOV: | 28-giu-2013 |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
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