Aging is associated with a gradual decline in cognitive functions, and more dramatic cognitive impairments occur in patients affected by Alzheimer’s disease (AD). Electrophysiological and molecular studies performed in aged animals and in animal models of AD have shown that cognitive decline is associated with significant modifications in synaptic plasticity (i.e., activity-dependent changes in synaptic strength) and have elucidated some of the cellular mechanisms underlying this process. Morphological studies have revealed a correlation between the quality of memory performance and the extent of structural changes of synaptic contacts occurring during memory consolidation. We briefly review recent experimental evidence here.
M. Balietti, F. Tamagnini, P. Fattoretti, C. Burattini, T. Casoli, D. Platano, et al. (2012). Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer’s disease. REJUVENATION RESEARCH, 15(2), 235-238 [10.1089/rej.2012.1318].
Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer’s disease
BURATTINI, COSTANZA;PLATANO, DANIELA;AICARDI, GIORGIO
2012
Abstract
Aging is associated with a gradual decline in cognitive functions, and more dramatic cognitive impairments occur in patients affected by Alzheimer’s disease (AD). Electrophysiological and molecular studies performed in aged animals and in animal models of AD have shown that cognitive decline is associated with significant modifications in synaptic plasticity (i.e., activity-dependent changes in synaptic strength) and have elucidated some of the cellular mechanisms underlying this process. Morphological studies have revealed a correlation between the quality of memory performance and the extent of structural changes of synaptic contacts occurring during memory consolidation. We briefly review recent experimental evidence here.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
