OBJECTIVE: The aim of the present prospective study was to obtain further insight into health-related quality of life (HR-QoL) as a predictor of survival in a selected cohort of patients with oral cancer. STUDY DESIGN: A total of 124 patients were treated with surgery or combined therapy. All of the recruited patients completed the European Organization for Research and Treatment of Cancer questionnaires QLQC30 and H&N35 on 4 occasions. Overall survival was assessed. Univariate and multivariate Cox proportional hazards regression models were conducted. RESULTS: High baseline HR-QoL score and high pain symptom score were significantly associated with a better survival (HR 0.86 and 0.92 respectively). Swallowing (HR 0.94), and speech (HR 0.92) high baseline scores were also significantly associated with a better survival in the adjusted analyses. CONCLUSIONS: Patients who reported a better HR-QoL at tumor diagnosis had a better survival than patients with a lower HR-QoL baseline score.
Tarsitano A., Pizzigallo A., Ballone E., Marchetti C. (2012). HEALTH-RELATED QUALITY OF LIFE AS A SURVIVAL PREDICTOR FOR PATIENTS WITH ORAL CANCER: IS QUALITY OF LIFE ASSOCIATED WITH LONG-TERM OVERALL SURVIVAL?. ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, 114(6), 756-763 [10.1016/j.oooo.2012.06.022].
HEALTH-RELATED QUALITY OF LIFE AS A SURVIVAL PREDICTOR FOR PATIENTS WITH ORAL CANCER: IS QUALITY OF LIFE ASSOCIATED WITH LONG-TERM OVERALL SURVIVAL?
TARSITANO, ACHILLE;PIZZIGALLO, ANGELO;MARCHETTI, CLAUDIO
2012
Abstract
OBJECTIVE: The aim of the present prospective study was to obtain further insight into health-related quality of life (HR-QoL) as a predictor of survival in a selected cohort of patients with oral cancer. STUDY DESIGN: A total of 124 patients were treated with surgery or combined therapy. All of the recruited patients completed the European Organization for Research and Treatment of Cancer questionnaires QLQC30 and H&N35 on 4 occasions. Overall survival was assessed. Univariate and multivariate Cox proportional hazards regression models were conducted. RESULTS: High baseline HR-QoL score and high pain symptom score were significantly associated with a better survival (HR 0.86 and 0.92 respectively). Swallowing (HR 0.94), and speech (HR 0.92) high baseline scores were also significantly associated with a better survival in the adjusted analyses. CONCLUSIONS: Patients who reported a better HR-QoL at tumor diagnosis had a better survival than patients with a lower HR-QoL baseline score.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
