Clinical presentation of canine parvovirus typically involves expression of a Systemic Inflammatory Response Syndrome (SIRS). The aim of this retrospective study was to characterize SIRS by measuring a panel of APPs [C-Reactive Protein (CRP), Haptoglobin (Hp), Transferrin (TIBC), Ferritin (FT), Fibrinogen (Fib), Albumin (Alb)] and other indirect biomarkers of flogosis [Total Iron (Fe), Antithrombin (AT), D-Dimers (D-D)] in dogs affected by parvovirus. Dogs with a confirmed diagnosis of parvovirus admitted at the University of Bologna - Veterinary Teaching Hospital (April 2006 - December 2009) were included. Upon admission, a clinical score (0-12), previously applied to dogs with parvovirus, was calculated and blood samples were collected by jugular venipuncture. Analytes were assayed on serum or plasma using specific methods on an automated chemistry analyzer. Blood samples from 28 healthy dogs (H) were also available as controls. A group of 58 dogs with parvovirus (P) meeting SIRS criteria, 33 males and 25 females, median age 2 months (range 1.5-48), was included: 49 survivors (Ps) and 9 nonsurvivors (Pn). Results of CRP, Hp, TIBC, F, Fib, Alb, TI and AT were all significantly different from H indicating the presence of an Acute Phase Response in P. Fib, Alb, Total Protein (TP), TIBC, AT values and red blood cells count were significantly lower, while heart rate and FT values were significantly higher in Pn than in Ps (p<0,05). Dogs with CRP values higher than 7.0 mg/dl showed significantly lower values of TI and % of transferrin saturation and higher values of clinical score, FT, D-D, Alb and TP (p<0,05). Dogs with Alb values lower than 2.0 g/dl showed significantly lower values of CRP, D-D, Fib, TIBC (p<0,05), Hct, TP and albumin-globulin ratio (p<0,0001). Measurement of a full profile of inflammatory biomarkers is helpful in the identification and a wider characterization of a SIRS in dogs affected by parvovirus. The presence of severe protein enteric loss and contraction of plasma volume upon admission, frequently encountered in these patients, could have had a potential influence on these results. A serial evaluation of these biomarkers of systemic inflammation during hospitalization, in order to verify their alterations in response to treatments, is strongly suggested to test their prognostic significance in course of this disease.
M. Giunti, F. Dondi, E. Sala Gutierrez, R. Isaya, M. Battilani, P. Famigli Bergamini, et al. (2010). EVALUATION OF THE ACUTE PHASE RESPONSE IN DOGS WITH PARVOVIRUS. VETERINARY CLINICAL PATHOLOGY, 900, 272-272.
EVALUATION OF THE ACUTE PHASE RESPONSE IN DOGS WITH PARVOVIRUS
GIUNTI, MASSIMO;DONDI, FRANCESCO;BATTILANI, MARA;FAMIGLI BERGAMINI, PAOLO;PELI, ANGELO
2010
Abstract
Clinical presentation of canine parvovirus typically involves expression of a Systemic Inflammatory Response Syndrome (SIRS). The aim of this retrospective study was to characterize SIRS by measuring a panel of APPs [C-Reactive Protein (CRP), Haptoglobin (Hp), Transferrin (TIBC), Ferritin (FT), Fibrinogen (Fib), Albumin (Alb)] and other indirect biomarkers of flogosis [Total Iron (Fe), Antithrombin (AT), D-Dimers (D-D)] in dogs affected by parvovirus. Dogs with a confirmed diagnosis of parvovirus admitted at the University of Bologna - Veterinary Teaching Hospital (April 2006 - December 2009) were included. Upon admission, a clinical score (0-12), previously applied to dogs with parvovirus, was calculated and blood samples were collected by jugular venipuncture. Analytes were assayed on serum or plasma using specific methods on an automated chemistry analyzer. Blood samples from 28 healthy dogs (H) were also available as controls. A group of 58 dogs with parvovirus (P) meeting SIRS criteria, 33 males and 25 females, median age 2 months (range 1.5-48), was included: 49 survivors (Ps) and 9 nonsurvivors (Pn). Results of CRP, Hp, TIBC, F, Fib, Alb, TI and AT were all significantly different from H indicating the presence of an Acute Phase Response in P. Fib, Alb, Total Protein (TP), TIBC, AT values and red blood cells count were significantly lower, while heart rate and FT values were significantly higher in Pn than in Ps (p<0,05). Dogs with CRP values higher than 7.0 mg/dl showed significantly lower values of TI and % of transferrin saturation and higher values of clinical score, FT, D-D, Alb and TP (p<0,05). Dogs with Alb values lower than 2.0 g/dl showed significantly lower values of CRP, D-D, Fib, TIBC (p<0,05), Hct, TP and albumin-globulin ratio (p<0,0001). Measurement of a full profile of inflammatory biomarkers is helpful in the identification and a wider characterization of a SIRS in dogs affected by parvovirus. The presence of severe protein enteric loss and contraction of plasma volume upon admission, frequently encountered in these patients, could have had a potential influence on these results. A serial evaluation of these biomarkers of systemic inflammation during hospitalization, in order to verify their alterations in response to treatments, is strongly suggested to test their prognostic significance in course of this disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
