Objective: Limited information is available on the sensibility and specificity of 18Ffluorodeoxyglucose positron emission computed tomography (FDG-PET/CT) for esophageal cancer clinical staging. Aim of the current study was to evaluate the diagnostic performance of FDG-PET/CT. Methods: Thirty one patients (28 men, median age 63 years r. 41–81) who underwent FDG-PET/CT and thoraco-abdominal CT-scan, were retrospectively evaluated. Lymph node (N) and presence/absence of distant (M1b) and nodal (N) metastases as determined by FDG-PET/CT and CT were assessed in relation to clinical patterns (for M) and pathology (for N). Esophagectomy and extended lymphadenectomy without prior neoadjuvant treatment was performed in 22 patients. Sensitivity, specificity, diagnostic accuracy and k statistics of the two imaging techniques were calculated. Results: Four tumors (13%) were located at the cervical esophagus (2 squamous cell carcinomas, 1 anaplastic cell carcinoma and 1 adenocarcinoma) 15 (48%) at the gastroesophageal junction (11 adenocarcinomas, of whom 6 with Barrett's metaplasia and 4 squamous cell carcinomas) and 12 (39%) at the thoracic esophagus (11 squamous cell carcinoma, 1 adenocarcinoma). At pathology, 18 patients (81%) had metastatic N, no distant metastatic disease was reported. Data on performance of the two imaging techniques are summarized in Table 1. Conclusions: FDG-PET/CT with respect to CT improves specificity in N and sensibility and specificity in M disease. FDG-PET/CT provides additional value for clinical staging of esophageal cancer versus CT and, in relation to the data of the literature, versus FDG-PET.
Ruffato A, Pilotti V, Fanti S, Catellucci P, Golemi A, Galassi R, et al. (2008). Sensibility and specificity of FDG PET/CT for preoperative staging of esophageal cancer. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 7 (Suppl. 2)(Suppl.2), S186: 141-P-S186: 141-P.
Sensibility and specificity of FDG PET/CT for preoperative staging of esophageal cancer
FANTI, STEFANO;MATTIOLI, SANDRO
2008
Abstract
Objective: Limited information is available on the sensibility and specificity of 18Ffluorodeoxyglucose positron emission computed tomography (FDG-PET/CT) for esophageal cancer clinical staging. Aim of the current study was to evaluate the diagnostic performance of FDG-PET/CT. Methods: Thirty one patients (28 men, median age 63 years r. 41–81) who underwent FDG-PET/CT and thoraco-abdominal CT-scan, were retrospectively evaluated. Lymph node (N) and presence/absence of distant (M1b) and nodal (N) metastases as determined by FDG-PET/CT and CT were assessed in relation to clinical patterns (for M) and pathology (for N). Esophagectomy and extended lymphadenectomy without prior neoadjuvant treatment was performed in 22 patients. Sensitivity, specificity, diagnostic accuracy and k statistics of the two imaging techniques were calculated. Results: Four tumors (13%) were located at the cervical esophagus (2 squamous cell carcinomas, 1 anaplastic cell carcinoma and 1 adenocarcinoma) 15 (48%) at the gastroesophageal junction (11 adenocarcinomas, of whom 6 with Barrett's metaplasia and 4 squamous cell carcinomas) and 12 (39%) at the thoracic esophagus (11 squamous cell carcinoma, 1 adenocarcinoma). At pathology, 18 patients (81%) had metastatic N, no distant metastatic disease was reported. Data on performance of the two imaging techniques are summarized in Table 1. Conclusions: FDG-PET/CT with respect to CT improves specificity in N and sensibility and specificity in M disease. FDG-PET/CT provides additional value for clinical staging of esophageal cancer versus CT and, in relation to the data of the literature, versus FDG-PET.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
